Registration Dossier

Administrative data

Description of key information

In accordance with REACH Annex XI, section 2, testing is technically not feasible as a consequence of the properties of the substance (hydrolytically unstable substance and quasi-instantaneously degraded in contact with moist skin or mucuous membranes to form Vanadium pentoxide and hydrogen chloride). There are sufficient data on the cleavage products (Vanadium pentoxide and hydrogen chloride were already registered in the frame of REACH) and the breakdown substance are exempted to Registration following Annex V (Entry I).

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Link to relevant study records
Reference
Endpoint:
short-term repeated dose toxicity: oral
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Critical effects observed:
not specified
Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - systemic effects

Link to relevant study records
Reference
Endpoint:
short-term repeated dose toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Critical effects observed:
not specified
Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Link to relevant study records
Reference
Endpoint:
short-term repeated dose toxicity: inhalation
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Critical effects observed:
not specified
Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Link to relevant study records
Reference
Endpoint:
short-term repeated dose toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Critical effects observed:
not specified
Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Link to relevant study records
Reference
Endpoint:
short-term repeated dose toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Critical effects observed:
not specified
Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Justification for classification or non-classification

Vanadium trichloride oxide quasi-instantaneously degraded in contact with moist skin or mucuous membranes to form Vanadium pentoxide and hydrogen chloride.

Testing Vanadium trichloride oxide for long term toxicity is for this reason not relevant at all, but breakdown products have to be considered (classification for Vanadium pentoxide and hydrogen chloride have been elaborated in the frame of REACH).

For these reasons, no classification could be set for repeated toxicity.