Registration Dossier
Registration Dossier
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EC number: 231-780-2 | CAS number: 7727-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
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- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to birds: dietary toxicity test
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not a GLP study but well described protocol
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A series of experiments was undertaken to further investigate the influence of diet composition on chick response to monensin supplementation. Experiments included dietary content of vanadium with broiler chicks to 4 weeks of age.
- GLP compliance:
- no
- Dose method:
- feed
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on preparation and analysis of diet:
- DIET PREPARATION
- Description and nutrient analysis of basal diet provided in study report: yes
- Preparation of doses: no data
HOMOGENEITY AND STABILITY OF TEST MATERIAL IN DIET
- How often was homogeneity and stability tested: no data
- When and at what dose levels were samples of treated food analyzed for stability and concentration during the study: no data
- Nominal concentration (mg/kg feed): 0, 5, 10 or 20 ppm V - Test organisms (species):
- other: chicks
- Details on test organisms:
- TEST ORGANISM
- Common name: Hubbard chicks
- Age at test initiation: 1 day old
- Weight at test initiation: not given
- Sexes used: males - Limit test:
- no
- Total exposure duration (if not single dose):
- 4 wk
- Post exposure observation period:
- no data
- No. of animals per sex per dose and/or stage:
- 4 replicates were used per dietary treatment
- Control animals:
- yes, plain diet
- Nominal and measured doses / concentrations:
- 0, 5, 10 or 20 ppm V added
- Details on test conditions:
- ACCLIMATION; no detail
TEST CONDITIONS (range, mean, SD as applicable)
- Brooder temperature: electrically heated battery, no other detail
- Photoperiod: continuous artificial lighting program
Feed and water were offered ad libitum. - Details on examinations and observations:
- MORTALITY / CLINICAL SIGNS: recorded daily
BODY WEIGHT: at beginning and the end of trial
FOOD CONSUMPTION: recorded weekly
OTHER: hepatic Rb and K were analysed from eight chicks per treatment. - Details on reproductive parameters:
- not studied
- Reference substance (positive control):
- no
- Duration (if not single dose):
- 4 wk
- Dose descriptor:
- NOEL
- Effect level:
- 5 mg/kg diet
- Conc. / dose based on:
- element
- Remarks:
- vanadium
- Basis for effect:
- body weight
- Duration (if not single dose):
- 4 wk
- Dose descriptor:
- LOEL
- Effect level:
- 10 mg/kg diet
- Conc. / dose based on:
- element
- Remarks:
- vanadium
- Basis for effect:
- body weight
- Executive summary:
A series of experiments was undertaken to further investigate the influence of diet composition on chick response to the antibiotic monensin supplementation. These experiments included dietary supplementation with vanadium content of 0, 5, 10 or 20 ppm, given to male chicks from one day old during 4 weeks.
Supplementing the diet with 10 or 20 ppm vanadium significantly reduced mean body weight, feed intake and feed efficiency.
5 mg/kg diet was determined as a NOEL for this study.
Reference
Supplementing the diet with 10 or 20 ppm vanadium significantly reduced mean body weight, feed intake and feed efficiency.
Based on the mean of 1116 g diet intake per chick within 4 weeks and due to the fact that no data is given on the body weight at one day old (only 703 g mean weight after 4 weeks), the corresponding NOEL could be calculated at 0.28 mg/kg bw/day.
Description of key information
Two entries were reported for toxicity to birds:
- The first one is a publication from Cervantes, 1985, where vanadium content of 0, 5, 10 or 20 ppm were given to male chicks from one day old during 4 weeks. Supplementing the diet with 10 or 20 ppm vanadium significantly reduced mean body weight, feed intake and feed efficiency. 5 mg/kg diet was determined as a NOEL for this study.
- The second one is a literature search completed according to the Eco-SSL guidance (U.S. EPA, 2003) which remained 36 papers containing data for avian test species. These papers were reviewed and data were extracted and scored according to the Eco-SSL guidance. Within the 36 reviewed papers, there were 132 results for biochemical, behavioural, physiology, pathology, reproduction, growth, and survival effects that had a Data Evaluation Score of >65 (sufficient to derive the Toxicity Reference Value).
The no-observed adverse effect (NOAEL) values for growth and reproduction are used to calculate a geometric mean NOAEL. A geometric mean of the NOAEL values for growth and reproduction was calculated at 1.19 mg vanadium/kg bw/day.
Toxicity to birds is not required for this dossier due to tonnage band, but were referenced for knowledge purpose and showed that it is not necessary to go ahead with testing.
Key value for chemical safety assessment
Additional information
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