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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non GLP, predated OECD guideline, but scientifically fully acceptable and well documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
BASF- Test:acute inhalation toxicity with rats exposed to a saturated atmosphere for max. 8h
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Hex-3-yne-2,5-diol
EC Number:
221-209-5
EC Name:
Hex-3-yne-2,5-diol
Cas Number:
3031-66-1
Molecular formula:
C6H10O2
IUPAC Name:
hex-3-yne-2,5-diol

Test animals

Species:
rat
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Remarks:
200 L/h
Analytical verification of test atmosphere concentrations:
no
Remarks on duration:
1 - 8 h
Concentrations:
saturated atmosphere
No. of animals per sex per dose:
20°C: 12 for the 8-hour exposure
40°C: 12 for the 1-hour exposure, 6 for the 3-hour exposure and 6 for the 8-hour exposure
Control animals:
no
Details on study design:
The test substance was offered as a vapour at 20°C resp. 40°C.

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: Lethality
Based on:
test mat.
Exp. duration:
1 h
Remarks on result:
other: Mortality 0/12 (40°C)
Sex:
not specified
Dose descriptor:
other: Lethality
Based on:
test mat.
Exp. duration:
3 h
Remarks on result:
other: Mortality 3/6 (40°C)
Sex:
not specified
Dose descriptor:
other: Lethality
Based on:
test mat.
Exp. duration:
8 h
Remarks on result:
other: Mortality 6/6 (40°C)
Mortality:
20°C: no deaths after 8 hours.
40°C: no deaths after 1-hour exposure, 3 animals died after 3-hour exposure and all (6) animals died after 8-hour exposure.
Clinical signs:
other: Attemption to escape, irritation of the mucous membrane at 20°C. Attemption to escape, irritation of the mucous membrane, dyspnea, apathy, staggering and tremor at 40°C.
Gross pathology:
Pulmonary congestion, congestion in the liver, degeneration of the liver, heart dilatation.

Applicant's summary and conclusion