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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vitro
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The in-vitro procedure is being subject to pre-validation and validation processes.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Substance tested in Sens-It-Iv programme
GLP compliance:
yes
Type of study:
other: Substance tested in Sens-It-Iv programme

Test material

Constituent 1

In vivo test system

Test animals

Species:
other: In-vitro assessment
Strain:
other: In-vitro assessment

Study design: in vivo (LLNA)

No. of animals per dose:
MUTZ-3 and THP-1 cells were used instead of animals.

Results and discussion

Any other information on results incl. tables

Effect of the substance 4 -butylbenzene-1,3 -diol on IL-8 and CD86 expression in MUTZ-3 and THP-1 cells : negative

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Remarks:
Migrated information
Conclusions:
4-Butylbenzene-1,3-diol : not classified as a skin sensitiser.
Executive summary:

The skin sensitisation potential of the substance 4-butylbenzene-1,3 -diol was assessed in the Sens-It-Iv programme. The effect of the substance on IL-18 CD86 expression in MUTZ-3 and THP-1 cells was found to be negative. It can be concluded that the substance is not sensitising.