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EC number: 233-713-2 | CAS number: 10326-41-7
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration (if not single dose):
- 14 d
- Dose descriptor:
- LC50
- Effect level:
- > 2 250 mg/kg bw
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Mortality and sub-lethal effects:
- There was an apparent dosage related effect on body weight of males at the 1350 mg/kg and 2250 mg/kg dosages for Days 0-3. There appeared to be no effect on feed consumption at any dosage.
- Further details on results:
- In conclusion, the acute oral LD50 value of SY-83 to the bobwhite for this study was determined to be greater than 2250 mg/kg, the highest dosage tested. There were no mortalities at any dosage tested. Based upon effects on male body weight at 1350 and 2250 mg/kg, the no- observed-effect dosage was 810 mg/kg.
- Validity criteria fulfilled:
- yes
- Conclusions:
- In conclusion, the acute oral LD50 value of SY-83 to the bobwhite for this study was determined to be greater than 2250 mg/kg, the highest dosage tested. There were no mortalities at any dosage tested. Based upon effects on male body weight at 1350 and 2250 mg/kg, the no-observed-effect dosage was 810 mg/kg.
- Executive summary:
The acute oral LD50 value of SY-83 to the bobwhite for this study was determined to be greater than 2250 mg/kg, the highest dosage tested. There were no mortalities at any dosage tested. Based upon effects on male body weight at 1350 and 2250 mg/kg, the no-observed-effect dosage was 810 mg/kg. Since lactic acid is an essential molecule for life and has an extensive role in metabolism, this may be just a result of an equilibrium shift in metabolic pathways.
This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the attached report in section 13 of IUCLID.
- Endpoint:
- short-term toxicity to birds: dietary toxicity test
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration (if not single dose):
- 8 d
- Dose descriptor:
- LC50
- Effect level:
- > 5 620 mg/kg diet
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration (if not single dose):
- 8 d
- Dose descriptor:
- NOEC
- Effect level:
- >= 5 620 mg/kg diet
- Conc. / dose based on:
- test mat.
- Basis for effect:
- other: any external observation
- Validity criteria fulfilled:
- not specified
- Conclusions:
- In conclusion, the dietary LC50 value of SY-83 to the mallard in this study was greater than 5620 ppm, the highest concentration tested. The no-observed-effect concentration was also 5620 ppm.
- Executive summary:
Controls - There were no mortalities in the control group. All birds were normal in appearance and behavior throughout the test period.
SY-83 - There were no signs of toxicity, abnormal behavior or mortality in any test group. All birds were normal in appearance and behavior throughout the test period. When compared to the control, there was no effect on body weight or feed consumption throughout the test period. The dietary LC50 value of SY-83 to the mallard in this study was greater than 5620 ppm, the highest concentration tested. The no-observed-effect concentration was also 5620 ppm.
This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the attached report in section 13 of IUCLID.
- Endpoint:
- short-term toxicity to birds: dietary toxicity test
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Justification for type of information:
- For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration (if not single dose):
- 8 d
- Dose descriptor:
- LC50
- Effect level:
- > 5 620 mg/kg diet
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Key result
- Duration (if not single dose):
- 8 d
- Dose descriptor:
- NOEC
- Effect level:
- >= 5 620 mg/kg diet
- Conc. / dose based on:
- test mat.
- Basis for effect:
- other: external observations of (any) abnormality
- Validity criteria fulfilled:
- yes
- Conclusions:
- In conclusion, the LC50 of SY-83 to the bobwhite in this study was greater than 5620 ppm, the highest concentration tested. No apparent treatment related mortalities occurred. The no-observed-effect concentration was 5620 ppm.
- Executive summary:
The LC50 of SY-83 to the bobwhite in this study was greater than 5620 ppm, the highest concentration tested. No apparent treatment related mortalities occurred. The no-observed-effect concentration was 5620 ppm.
This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the attached report in section 13 of IUCLID.
- Endpoint:
- long-term toxicity to birds: reproduction test
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Referenceopen allclose all
Description of key information
In view of the general lack of systemic toxicity of lactic acid, being an endogenous metabolite both in mammals and birds, a test of reproductive toxicity in birds is not considered to be required. Nevertheless, available studies on L(+)-lactic acid are used for read-across to evaluate the toxicity to birds.
In all three studies the substance seems not be toxic to birds:
LD50 (14d, Colinus virginiaunus) > 2250 mg/kg (highest dosage tested); no mortalities occured; NOEC (male weight) = 810 mg/kg
LC50 (8d, Colinus virginianus and 8d, Anas platyrhynchos) > 5620 ppm (highest dosage tested); no mortalities occurred; NOEC = 5620 ppm
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
