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Physical & Chemical properties

Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.
Reason / purpose for cross-reference:
read-across source
Medium:
methanol
Solubility:
78.6 other: % w/w
Temp.:
20 °C
Medium:
ethanol
Solubility:
70.9 other: % w/w
Temp.:
20 °C
Medium:
other: n-propanol
Solubility:
62.4 other: % w/w
Temp.:
20 °C
Medium:
isopropanol
Solubility:
63.4 other: % w/w
Temp.:
20 °C
Medium:
n-butanol
Solubility:
54.5 other: % w/w
Temp.:
20 °C
Medium:
other: 2-ethylhexanol
Solubility:
29 other: % w/w
Temp.:
20 °C
Medium:
other: hexane
Solubility:
0.005 other: % w/w
Temp.:
20 °C
Medium:
toluene
Solubility:
0.11 other: % w/w
Temp.:
20 °C
Medium:
diethyl ether
Solubility:
38.7 other: % w/w
Temp.:
20 °C
Medium:
other: tetrahydrofuran
Solubility:
65.1 other: % w/w
Temp.:
20 °C
Test substance stable:
yes
Conclusions:
Lactic acid is soluble in most polar solvents, but sparingly soluble to insoluble in nonpolar solvents like hexane and toluene.
Executive summary:

The objective of this piece of research was to determine the solubility of lactic acid (crystals) in a number of common organic solvents and Purac products. With the results the best solvent(s) could be chosen to wash lactic acid crystals. Another objective was to increase the basic knowledge on lactic acid. Results were obtained by stirring dry lactic acid crystals at a certain temperature in a solvent. After 0.75–1 hour a sample was taken and analyzed for lactic acid (free acidity). The results are for pure monomeric lactic acid, therefore the solubility for lactic acid containing oligomers and/or water can be different.

Lactic acid is soluble in most polar solvents, but sparingly soluble to insoluble in nonpolar solvents like hexane and toluene.

This information is used in a read-across approach in the assessment of the target substance. For details and justification of read-across please refer to the read-across report attached to IUCLID section 13.

Description of key information

Lactic acid is soluble in most polar solvents, but sparingly soluble to insoluble in nonpolar solvents like hexane and toluene.

Key value for chemical safety assessment

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