Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 415-670-3 | CAS number: 78850-37-0 GR138766X
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (In vivo micronucleus study)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test animals
- Species:
- other: Mouse (CD-1)
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- Arachis oil
- No. of animals per sex per dose:
- Male: 0 mg/kg; No. of animals: 7; Sacrifice time: 24 hours
Male: 0 mg/kg; No. of animals: 7; Sacrifice time: 48 hours
Male: 2000 mg/kg; No. of animals: 7; Sacrifice time: 24 hours
Male: 2000 mg/kg; No. of animals: 7; Sacrifice time: 48 hours
Male: 1000 mg/kg; No. of animals: 7; Sacrifice time: 24 hours
Male: 500 mg/kg; No. of animals: 7; Sacrifice time: 24 hours
Results and discussion
Test results
- Toxicity:
- yes
- Remarks:
- Doses producing toxicity: There were no deaths, and no clinical signs of toxicity were observed. No statistically significant decreases in the PCE/NCE ration were observed in the 24 and 48-hour test groups when compared to controls.
- Additional information on results:
- Observations:
There was no evidence of a significant increase in the
incidence of micronucleated polychromatic erythrocytes in
test group animals compared to vehicle controls. The
positive control material produced a marked increase in the
frequency of micronucleated polychromatic erythrocytes.
Negative control values were within historical ranges.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
