Methyl (3aR,4R,7aR)-2-methyl-4-(1S,2R,3-triacetoxypropyl)-3a,7a-dihydro-4H-pyrano[3,4-d]oxazole-6-carboxylate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Adequacy of study:

other information

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Annex V

GLP compliance:

yes

Limit test:

yes

Test animals

Species:

other: rat, Sprague-Dawley

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

other: Moistened with arachis oil BP

Duration of exposure:

24 h

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Mortality:

Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels: No deaths occured. No signs of systemic toxicity were noted during the study period. No toxicologically significant effects on bodyweight were noted during the study.

Gross pathology:

Effects on organs:
No abnormalities were noted at necropsy of animals killed at
the end of the study.

Other findings:

Signs of toxicity (local):
No signs of dermal irritation were noted during the study
period.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU