Registration Dossier
Registration Dossier
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EC number: 255-982-5 | CAS number: 42872-30-0
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Consistent test but without details of documents and no indication of GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Het Cam test
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-(m-benzoylphenyl)propionitrile
- EC Number:
- 255-982-5
- EC Name:
- 2-(m-benzoylphenyl)propionitrile
- Cas Number:
- 42872-30-0
- Molecular formula:
- C16H13NO
- IUPAC Name:
- 2-(3-benzoylphenyl)propanenitrile
- Details on test material:
- Test article: BPPN, an intermediate product of Ketoprofen synthesis
Batch: BPPN-E630
Constituent 1
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- no indication of irritation
Any other information on results incl. tables
No data
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- BPPN (batch BPPN-E630), an intermediate product of Ketoprofen synthesis, was non-irritant to the eye. It does not require labeling with any classifciation.
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