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Physical & Chemical properties

Melting point / freezing point

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Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From 16 May 2012 to 25 January 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
2012-12-15
Type of method:
differential scanning calorimetry
Key result
Melting / freezing pt.:
>= 60.9 - <= 61.9 °C
Atm. press.:
1 013 hPa

Six assays were performed during the test, the temperature values obtained for the melting point varied between 52.6 and 67.7 °C.

The mean value for the melting point a is explained as the mean of at least two assays for which the melting point value or the boiling point value are in the range of the estimated accuracy of the method: ± 0.5 °C up to 326.9 °C and ± 2.0 °C

above 326.9 °C.

Two assays were contained between the range for the melting point.

Assays No. Melting point (°C)
1 /
2 67.7
3 52.6
4 62.3
5 61.5
6 61.2

/ corresponds to the non integration of the curve.

The results written in bold were taken into account.

Conclusions:
The mean melting point of the test item was 61.4 ± 0.5 °C.
Executive summary:

The melting point of the test item (= substance EC 939-455-3) was investigated in a GLP-compliant study performed in accordance with OECD Guideline 102 (Melting point / Melting Range) and EU Method A.1 (Melting / Freezing Temperature). The mean melting point of the test item was 61.4 ± 0.5 °C.

Description of key information

The melting point of the substance 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3) was investigated in a GLP-compliant study (Ricau, 2013) performed in accordance with OECD Guideline 102 (Melting point / Melting Range) and EU Method A.1 (Melting / Freezing Temperature). The mean melting point of the substance was 61.4 ± 0.5 °C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:
61.4 °C

Additional information

The melting point of the substance 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3) was investigated in a GLP-compliant study (Ricau, 2013) performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and was selected as key study for the endpoint.