1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts

Oxidising properties

Link to relevant study record(s)

Reference

Endpoint:

oxidising liquids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 04 December 2012 to 15 February 2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test O.2 (Test for oxidizing liquids)

Deviations:

yes

Remarks:

The mean pressure rise time for sodium chlorate/cellulose mixture recorded was slower than expected . As the mean pressure rise time of test item/cellulose was even slower, this deviation was not considered to have affected the results.

Qualifier:

according to guideline

Guideline:

UN Manual of Tests and Criteria: Test O.2 (Test for oxidizing liquids)

Deviations:

yes

Remarks:

The 0.3-mm thickness of the aluminium bursting disk differed from the one prescribed by the guideline. This deviation was not considered to have affected the results.

GLP compliance:

yes (incl. QA statement)

Remarks:

2010-12-15

Contact with:

powdered cellulose

Sample tested:

reference mixture with 50% perchloric acid + cellulose (1:1 ratio)

Parameter:

mean pressure rise time

Result:

52 ms

Sample tested:

reference mixture with 40% aqueous sodium chlorate + cellulose (1:1 ratio)

Parameter:

mean pressure rise time

Result:

12 164 ms

Sample tested:

reference mixture with 65% nitric acid + cellulose (1:1 ratio)

Parameter:

mean pressure rise time

Result:

3 486 ms

Key result

Sample tested:

test mixture 1:1

Parameter:

mean pressure rise time

Result:

23 700 ms

Results

Preparation of the fibrous cellulose

Drying time                           1 day, 16 hours and 50 min

Drying temperature              Between 101.0 and(mean)

 

Mixtures with reference item / cellulose

With 50% perchloric acid aqueous solution as reference item

Assay No.	Reference item mass(g)	Cellulose mass (g)	Atmospheric pressure(kPa)	Corrected pressure rise time(ms)	Mean corrected pressure rise time(ms)	Theorical calculated min and max accepted value: ± 30% of the mean pressure rise time(ms)
1	2.50	2.50	98.6	53	52	[36 ; 68]
4	2.50	2.50	98.6	62
6	2.50	2.50	98.6	45
7	2.49	2.50	98.6	52
10	2.50	2.50	97.6	46

Remark: Five other assays were performed, but due to the speed of the reaction, some values were missing for the calculation of the pressure rise time.

 

With 40% sodium chlorate aqueous solution as reference item

 First series:

Assay No.	Reference item mass(g)	Cellulose mass (g)	Atmospheric pressure(kPa)	Corrected pressure rise time(ms)	Mean corrected pressure rise time(ms)	Theorical calculated min and max accepted value: ± 30% of the mean pressure rise time(ms)
2	2.50	2.50	98.5	9986	13665	[9565 ;]
3	2.50	2.50	98.5	15417
4	2.50	2.50	98.5	13870
5	2.50	2.50	98.4	16280
7	2.50	2.50	97.6	12771

Remark: Two other assays were performed but one was not taken into account as it did not comply with the quality criteria and the other one did not rise P_atm+ 2070 kPa.

The results were not, as expected around 2500 ms, between the mean pressure rise time of the aqueous nitric acid / cellulose mixture and that of the perchloric acid / cellulose mixture. Another series was performed with sodium chlorate of another provider. This first series was not taken into account.

Second series:

Assay No.	Reference item mass(g)	Cellulose mass (g)	Atmospheric pressure(kPa)	Corrected pressure rise time(ms)	Mean corrected pressure rise time(ms)	Theorical calculated min and max accepted value: ± 30% of the mean pressure rise time(ms)
1	2.50	2.50	98.8	9129	12164	[8515 ; 15813]
2	2.50	2.50	98.8	10617
3	2.50	2.50	98.8	12378
4	2.50	2.50	98.8	14863
5	2.50	2.50	98.8	13831

 

The results of the second series were slightly lower than the results of the first series, but they were not around 2500 ms as indicated in the standard procedure.This second series was taken into account.

 

With 65% nitric acid aqueous solution reference item

Assay No.	Reference item mass(g)	Cellulose mass (g)	Atmospheric pressure(kPa)	Corrected pressure rise time(ms)	Mean corrected pressure rise time(ms)	Theorical calculated min and max accepted value: ± 30% of the mean pressure rise time(ms)
1	2.50	2.50	98.3	4338	3486	[2440 ; 4532]
2	2.51	2.50	98.3	3485
4	2.50	2.50	98.3	4062
5	2.50	2.50	97.4	2815
6	2.51	2.50	97.4	2728

 Remark: Another assay was performed but it was not taken into account as it did not comply with the quality criteria.

 

Mixtures with test item / cellulose

Assay No.	Test item mass (g)	Cellulose mass (g)	Atmospheric pressure(kPa)	Corrected pressure rise time(ms)	Mean corrected pressure rise time(ms)	Theorical calculated min and max accepted value: ± 30% of the mean pressure rise time(ms)
1	2.49	2.50	97.6	23301	23700	[16590 ; 30810]
2	2.51	2.50	97.6	21758
3	2.50	2.50	97.6	23249
5	2.50	2.50	97.6	24782
8	2.50	2.50	97.6	25411

 Remark: Three other assays were performed but were not taken into account as they did not comply with the quality criteria.

The mean pressure rise time obtained with the test item / cellulose mixture was slower than the mean pressure rise time obtained with the three mixtures of reference item / cellulose.

 

The test item was not classified as an oxidizing liquid of Division 5.1 and thus was not assigned to any packing group,under the experimental conditions used.

Interpretation of results:

GHS criteria not met

Conclusions:

The mean pressure rise time obtained with the test item / cellulose mixture was slower than the mean pressure rise time obtained with the three mixtures of reference item / cellulose. The test item was not classified as an oxidizing liquid of Division 5.1 and thus was not assigned to any packing group, under the experimental conditions used.

Executive summary:

The oxidizing properties of the test item (= substance EC 939-455-3 in aqueous commercial product) were investigated in a GLP-compliant study performed in accordance with UN Manual of Tests and Criteria: Test O.2 (Test for oxidizing liquids). The mean pressure rise time obtained with the test item / cellulose mixture was slower than the mean pressure rise time obtained with the mixtures of reference item / cellulose. The test item was not classified as an oxidizing liquid of Division 5.1 and thus was not assigned to any packing group, under the experimental conditions used.

The study was performed on a commercial product (aqueous solution) as the substance EC 939-455-3 is manufactured and used in a liquid form.

Description of key information

The oxidizing properties of the substance 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3) in aqueous solutions were investigated in a GLP-compliant study (Demangel, 2013) performed in accordance with UN Manual of Tests and Criteria: Test O.2 (Test for oxidizing liquids). The mean pressure rise time obtained with the substance / cellulose mixture was slower than the mean pressure rise time obtained with the mixtures of reference item / cellulose.

The study was performed on a commercial product (aqueous solution) as the substance EC 939-455-3 is manufactured and used in a liquid form.

Key value for chemical safety assessment

Oxidising properties:

no

Additional information

The oxidizing properties of the substance 1-Propanaminium, N-(3-aminopropyl)-2-hydroxy-N,N-dimethyl-3-sulfo-, N-(C8-18(even numbered) acyl) derivs., hydroxides, inner salts (EC 939-455-3) in aqueous solution were investigated in a GLP-compliant study (Demangel, 2013) performed in accordance with standard methods, with minor deviations. The study is considered as reliable (Klimisch 1) and was selected as key study for the endpoint.

Justification for classification or non-classification

The oxidizing properties of the registered substance in water (C8 -18 cocamidopropyl hydroxsultaine) were determined according to Carriage of dangerous goods – Manual of tests and criteria (fifth edition) United nations (2009)– O.2 test and GLP. Two deviations were observed during the study.

The 0.3-mm thickness of the aluminium bursting disk differed from the one prescribed by theguideline. This modification did not affect the quality or the interpretation of the results obtained.

The mean pressure rise time obtained with the sodium chlorate/ cellulose mixture recorded was 12164 ms instead of about 2500 ms as expected following the standard procedure. Another batch of sodium chlorate from another provider was tested and the results were similar. As the mean pressure rise time of the test item / cellulose mixture was slower (23700 ms), this deviation was not considered to have affected the quality or the interpretation of the results obtained.