Registration Dossier
Registration Dossier
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EC number: 259-700-1 | CAS number: 55542-26-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- Nov to Dec 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: well reported Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- 17 beta-Hydroxy-17 alpha-(3-hydroxy-1-propynyl)-4-androsten-3-one
- IUPAC Name:
- 17 beta-Hydroxy-17 alpha-(3-hydroxy-1-propynyl)-4-androsten-3-one
- Details on test material:
- - Name of test material (as cited in study report): ZK 4829
- Batch No.: 59002501
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: physiol. saline + Myrj 53 in bidest.water
- Doses:
- 2000 mg/kg (application volume 10 mL/kg)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No animal died in the course of the study and no clinical signs were observed.
One male and one female showed significantly reduced body weight gain.
No abnormalities were observed at necropsy.
Applicant's summary and conclusion
- Executive summary:
The single oral administration of the test substance (ZK 4829) to male and female rats at a dose of 2000 mg/kg was tolerated without any mortality. No compound-related clinical signs were observed and there were no macroscopic pathological signs. One male and one female animal showed significantly reduced body weight gain.
The acute oral toxicity of Hydroxypropinol in rats is therefore above 2000 mg/kg body weight.
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