Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-605-2 | CAS number: 123-15-9
Endpoint summary
Administrative data
Description of key information
The LD50/LC50 values derived from the key-studies were: LD50 (oral, rat) > 5000 mg/kg bw and LC50 (rat, inhal.) > 8.4 g/m³.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 8 400 mg/m³ air
Additional information
Acute toxicity: oral
The acute oral toxicity of 2-Methylpentanal in the rat was examined according to OECD TG 423 and GLP (ARC, 2008).Two groups of 3 female rats were treated at a dose of 2000 mg/kg bw by oral gavage. During the 14-day observation period neither mortality nor clinical signs were noted. Body weight development was not impaired and no changes were observed at necropsy. As no mortality occurred at 2000 mg/kg bw a LD50 > 5000 mg/kg bw can be assumed acc. to OECD TG 423. This is supported by an older oral toxicity study in the rat (BASF AG, 1977) where a LD50 of ca. 6400 mg/kg bw was determined.
Acute toxicity: inhalation
In an acute inhalation study following the principles of OECD TG 403 groups of 10 rats per sex were whole body exposed to 8.4 mg 2-Methylpentanal/L (analytically measured) for 4 h and subsequently observed for 14 days (BASF AG, 1978). All animals survived. As clinical signs accelerated respiration, crusted noses and rough fur occurred. No animal showed any abnormal finding at necropsy. Body weight development was not impaired.
Consequently, a LC50 > 8.4 mg/L air was determined. In a supporting study no mortality of rats was observed in an atmosphere enriched with the test substance at 20 °C (vapor) after an exposure of 8 hours (BASF, 1977).
Justification for classification or non-classification
Based on the results for acute oral (LD50 rat > 5000 mg/kg bw) and inhalation toxicity (LC50 > 8.4 mg/L), 2-Methylpentanal is not subject for classification according to Directive 67/548/EEC and Regulation 1272/2008/EC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
