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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from Authoritative database.

Data source

Reference
Reference Type:
other: authoritative database
Title:
Acute oral toxicity by using test chemical
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
ChemIDplus

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
The acute oral toxicity test of the given test chemical in rat.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
5-chloro-2,3-dihydro-1,3-benzoxazole-2-thione
Cas Number:
22876-19-3
Molecular formula:
C7H4ClNOS
IUPAC Name:
5-chloro-2,3-dihydro-1,3-benzoxazole-2-thione
Details on test material:
- Name: 5-chloro-2,3-dihydro-1,3-benzoxazole-2-thione
- InChI: 1S/C7H4ClNOS/c8-4-1-2-6-5(3-4)9-7(11)10-6/h1-3H,(H,9,11)
- Smiles: c12c(nc(o1)S)cc(Cl)cc2
- Molecular formula:C7H4ClNOS
- Molecular weight :185.634 g/mol
- Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
1000 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw
Based on:
test mat.
Mortality:
50% mortality was observed at 1000 mg/kg bw in treated animals.
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute oral LD50 value was considered to be 1000 mg/kg bw, when rats was treated with the given test chemical via oral route.
Executive summary:

Acute oral toxicity study of the given test chemical was conducted in rats at the concentration of 1000 mg/kg bw.

Animals were observed for mortality. 50% mortality was observed at 1000 mg/kg bw in treated animals.

Hence, the LD50 value was considered to be 1000 mg/kg bw, when rats was treated with the given test chemical via oral route.