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EC number: 253-326-2 | CAS number: 37052-78-1
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23.03.2013 - 09.04.2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Justification for type of information:
- Experimental test result performed using standard test guidelines
- Qualifier:
- according to guideline
- Guideline:
- other: Gravimetric method
- Principles of method if other than guideline:
- Weight of the chemical substance (fat) to dissolve in Organic Solvent to form a homogeneous solution of the solute in the solvent
- GLP compliance:
- no
- Specific details on test material used for the study:
- - Name of test material : 5-methoxy-1,3-dihydro-2H-benzimidazole-2-thione
- Molecular formula : C8H8N2OS
- Molecular weight : 180.2302 g/mol
- Smiles notation : COc1ccc2c(c1)nc([nH]2)S
- InChl : 1S/C8H8N2OS/c1-11-5-2-3-6-7(4-5)10-8(12)9-6/h2-4H,1H3,(H2,9,10,12)
- Substance type : Organic
- Physical state : Solid - Key result
- Medium:
- methanol
- Solubility:
- 4 100 mg/L
- Temp.:
- 37 °C
- Remarks on result:
- other: No other detail available
- Key result
- Medium:
- other: Petroleum
- Solubility:
- 50 mg/L
- Temp.:
- 37 °C
- Remarks on result:
- other: No other detail available
- Conclusions:
- Based on the gravimetric method, the experimental value of solubility of test chemical in methanol at temperature of 37 Deg C was determine to be 4100 mg/L indicating that test chemical is soluble in methanol. Similarly experimental value of solubility in Petroleum ether at temperature of 37 Deg C was determine to be 50 mg/L indicating that test chemical is slightly soluble in Petroleum ether.
- Executive summary:
Based on the gravimetric method, the experimental value of solubility of test chemical in methanol at temperature of 37 Deg C was determine to be 4100 mg/L indicating that test chemical is soluble in methanol. Similarly experimental value of solubility in Petroleum ether at temperature of 37 Deg C was determine to be 50 mg/L indicating that test chemical is slightly soluble in Petroleum ether.
Reference
Description of key information
Based on the gravimetric method, the experimental value of solubility of test chemical in methanol at temperature of 37 Deg C was determine to be 4100 mg/L indicating that test chemical is soluble in methanol. Similarly experimental value of solubility in Petroleum ether at temperature of 37 Deg C was determine to be 50 mg/L indicating that test chemical is slightly soluble in Petroleum ether.
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 2 216 mg/L
Additional information
Based on the gravimetric method, the experimental value of solubility of test chemical in methanol at temperature of 37 Deg C was determine to be 4100 mg/L indicating that test chemical is soluble in methanol. Similarly experimental value of solubility in Petroleum ether at temperature of 37 Deg C was determine to be 50 mg/L indicating that test chemical is slightly soluble in Petroleum ether.
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