Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-929-8 | CAS number: 4559-86-8
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
- The biodegradation of tetrabutyl urea was investigated in a study
conducted according to OECD Guideline 301 F. The substance proved to be
not readily biodegradable under the test conditions employed (<=1.3%
biodegradation after 28 d). In the toxicity control containing both test
and reference item 32.2% biodegradation occurred within 14 d thus
indicating that the test item was not inhibitory to the inoculum at the
concentration tested. Tests on the inherent biodegradability are not
available.
Experimentally derived results on the bioaccumulation of tetrabutyl urea are not available. Based on a measured partition coefficient n-octanol/water coefficient (log Kow) of 6.2 (at 25°C) and a calculated log Kow of 5.69 (at 25°C), a high bioaccumulation could expected. However, based on calculated bioaccumulation factors (BCF) of 112 L/kg ww (regression based method) and 166 (Arnot-Gobas method) a low potential for bioaccumulation is to be assumed.
Based on the results on short-term toxicity of tetrabutyl urea to aquatic organisms, the lowest L(E)C50 was determined to be >0.1 mg/L in short-term toxicity testing.The substance is not classified as carcinogenic (category 1 or 2), mutagenic (category 1 or 2), or toxic for reproduction (category 1, 2 or 3) according to Directive 67/548/EEC (or the DSD) or carcinogenic (category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B or 2) according to Regulation EC No 1272/2008 (or CLP Regulation). No other evidence of chronic toxicity, as identified by the classifications: T, R48, or Xn, R48 according to Directive 67/548/EEC or specific target organ toxicity after repeated exposure (STOT RE category 1 or 2) according to Regulation EC No 1272/2008 is available.
These data indicate that tetrabutyl urea is not to be regarded as a substance exhibiting PBT or vPvB properties according to the criteria of REACH Directive, Article 14.3 (d) and the Technical Guidance Document (TGD) R.11 of the European Chemicals Agency.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
