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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Safety evaluation of a medium- and long-chain triacylglycerol oil produced from medium-chain triacylglycerols and edible vegetable oil
Author:
Matulka, R.A. et al.
Year:
2006
Bibliographic source:
Food Chem Toxicol. 44(9):1530-8.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
only basic data given
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: rat
Mortality:
All rats administered an acute dose of MLCT at 5000 mg/kg survived.
Clinical signs:
There were no abnormal clinical signs.
Body weight:
All rats administered an acute dose of MLCT at 5000 mg/kg showed typical body weight gain throughout the observation period, with no significant differences compared with the control group.
Gross pathology:
There were no gross pathological abnormalities in any organ/tissue in the external, cephalic, thoracic or abdominal regions in any of the male or female rats in the 5000 mg/kg groups following the observation period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU