Registration Dossier
Registration Dossier
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EC number: 200-350-6 | CAS number: 57-83-0
Dissociation constant
Administrative data
Link to relevant study record(s)
Description of key information
GLP study (UV measurements) for estimation of the acid base properties, supported by calculation with a computer program.
Analytical Development Physical Chemistry, Schering AG Berlin. Study report No. A27063 (ADP 2005_062), dated 2005-04-13.
Result: Progesterone can be considered as a neutral molecule in the pH range 1 to 13.
Key value for chemical safety assessment
Additional information
The UV/VIS spectra of progesterone were measured at 25°C in 0.1 M HCl (approx. pH1), 0.1 M KOH (approx. pH13) and a buffer solution of pH7.
No significant spectral change was observed.
The pKa calculation with the computer program ACD/pKa DB gave no result.
Therefore, progesterone is to be considered as a neutral molecule in the pH range 1 – 13.
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