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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
testing starting date 1993-02-03; testing terminating date 1993-03-19: reporting date 1993-04-26
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically well performed study; Guideline study; GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
5,8,11,14,17-pentaoxahenicosane; 5,8,11,14-tetraoxaoctadecane
EC Number:
940-417-3
Molecular formula:
C14H30O4 C16H34O5
IUPAC Name:
5,8,11,14,17-pentaoxahenicosane; 5,8,11,14-tetraoxaoctadecane
Test material form:
gas under pressure: refrigerated liquefied gas
Details on test material:
- Name of test material :Triethylenglykoldibutylether
- CAS: 63512-36-7
- Molecular formula : C14H30O4
- Molecular weight : 263 g/mol
- Physical state: liquid
- Storage condition of test material: in darkness at room temperature under chemical fume hood
- Solubility: 2g/L in water
- Melting point: -42 °C
- Boiling point: 283 °C
- Density: 0.9169 mg/l at 20 °C

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: one eye was treated and the other eye was used as control
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): undiluted

Duration of treatment / exposure:
Single appication
Observation period (in vivo):
Observation at 1, 24, 48 and 72 hours
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24, 48, 72 h
Score:
0
Max. score:
0
Irritation parameter:
iris score
Basis:
mean
Time point:
other: 24, 48, 72h
Score:
0
Max. score:
0
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24, 48,72
Score:
0.2
Max. score:
1
Reversibility:
fully reversible within: 48 hours
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24, 48, 72h
Score:
0
Max. score:
0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
No classification is to be assigned to the registration substance with respect to the endpoint eye irritation.
Executive summary:

The eye irritation property of the registration substance was investigated according to the OECD Guideline 405. Triethylenglycoldibutylether (representative material for the registration substance) was given into one eye of three rabbits each at dose of 0.1 ml. The animals exhibited transient conjuctivae redness, maximal scores being one. No significant eye irritation property was found for the registration substance.