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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
testing starting date 1993-01-06; testing finishing date 1993-01-20; reporting date 1993-02-28
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically well performed study; Guideline study; GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993
Report date:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
5,8,11,14,17-pentaoxahenicosane; 5,8,11,14-tetraoxaoctadecane
EC Number:
940-417-3
Molecular formula:
C14H30O4 C16H34O5
IUPAC Name:
5,8,11,14,17-pentaoxahenicosane; 5,8,11,14-tetraoxaoctadecane
Test material form:
gas under pressure: refrigerated liquefied gas
Details on test material:
- Name of test material :Triethylenglykoldibutylether
- CAS: 63512-36-7
- Molecular formula : C14H30O4
- Molecular weight : 263 g/mol
- Physical state: liquid
- Storage condition of test material: in darkness at room temperature under chemical fume hood
- Solubility: 2g/L in water
- Melting point: -42 °C
- Boiling point: 283 °C
- Density: 0.9169 mg/l at 20 °C

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: sesame oil
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 20% (weight/volume)
- Amount of vehicle (if gavage): 10 mg/kg


Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Unspecific toxicity observed on day of application. No further effects were observed.

Any other information on results incl. tables

On day of application the treated animals responded with unspecific intoxication signs. These included increased respiration rate, irregualr respiration, stupor, coat bristling, flanks drawn in, stilted gait, ataxic gait, prone position, squatting posture, clonic convulsions, trembling, fissure narros, narcosis, no corneal reflex, reduced pawreflex to pincing, no pawreflex to pinching, no lacing reaction and creased spontaneous activity. All these effects disappeared within 24 hours. The treated animals exhibited normal body weight development in the observation period of 14 days.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
No classification is assigned for the registration substance for the endpoint acute oral toxicity.
Executive summary:

The acute oral toxicity of the registration substance was investigated according to the OECD Guideline 401. 5 male and 5 female rats were treated with triethyleneglycoldibutylether (representative material for the registration substance) at dose of 2000 mg/kg bw via gavage. No mortality occured. On the application day unspecific toxicity signs were observed, which disappeared within 24 hours. The treated animals exhibited normal body weight development in the observation period of 14 days. The acute oral toxicity of the registration substance is found to be of no concern.