Registration Dossier
Registration Dossier
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EC number: 214-272-5 | CAS number: 1118-92-9
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- no
- Remarks:
- Statement of study director: GLP equivalent study conduct and documentation
Test material
- Reference substance name:
- 67359-57-3
- EC Number:
- 614-052-2
- Cas Number:
- 67359-57-3
- IUPAC Name:
- 67359-57-3
- Reference substance name:
- N,N-Dimethyldecan-1-amide, mixture with N,N-Dimethyloctanc-1-amide
- IUPAC Name:
- N,N-Dimethyldecan-1-amide, mixture with N,N-Dimethyloctanc-1-amide
- Details on test material:
- - Lot/batch No.: EO 6212107 v. 04.06.92
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
Test conditions
- Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
Results and discussion
Effect concentrations
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 212.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- - Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: none stated
- Effect concentrations exceeding solubility of substance in test medium: not stated - Results with reference substance (positive control):
- - Results with reference substance valid? Yes
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- In a study according to OECD Test Guideline 209, the EC50 to activated sludge of the test substance was determined to be 212.3 mg/l.
- Executive summary:
A study according to OECD test guideline 209 with activated sludge of a predominantly domestic sewage was perfomed to assess the toxicity of the test substance to microorganisms. The study was conducted and documented equivalent to GLP. The test substance was applied directly (no vehicle was used) for 3h in a static freshwater system. Analytics were not performed. All validity criteria were met. The EC50 to activated sludge of the test substance was determined to be 212.3 mg/l based on the respiration rate.
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