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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Summray from a publically available document.

Data source

Reference
Reference Type:
secondary source
Title:
Alkenes, C6-10, hydroformylation products, high boiling.
Author:
BASF Corporation
Year:
2003
Bibliographic source:
U.S. EPA HPV Challenge Program Submission

Materials and methods

Test material

Constituent 1
Reference substance name:
Alkenes, C6-10, hydroformylation products, high-boiling
EC Number:
271-230-9
EC Name:
Alkenes, C6-10, hydroformylation products, high-boiling
Cas Number:
68526-82-9
Molecular formula:
None available
IUPAC Name:
Alkenes, C6-10, hydroformylation products, high-boiling

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

A subchronic aerosol inhalation study of CAS# 68526 -82 -6 was conducted in 1987 (24). Groups of 15 Sprague-Dawley rats of each sex were exposed to atmospheres containing the test substance six hours a day, five days a week for 13 weeks. The target levels of test substance were 0, 100, 300, and 1000 mg/m3 and the achieved concentrations were very near target levels. Clear treatment related effects were observed in rats from the high-dose group manifest as reduced body weight gains, increased lung weights and microscopic pulmonary morphology. Mid-dose group animals exhibited an increase in lung weigh only for males and microscopic effects that were considered by the examining pathologist to be indicative of a “physiological response to aerosol exposure” and of questionable toxicological significance. In light of the dose-response continuum and minimal microscopic effects at the low dose, the mid dose is considered a LOAEL and the low dose is considered a NOAEL. The only target organ identified was the respiratory tract where necrosis of olfactory-respiratory epithelium was observed in numerous treated animals but not in controls. Additionally, mid and high-dose animals showed interstitial inflammation of the lungs in rats. No changes attributed to treatment in any organ system related to reproductive function were mentioned in the laboratory report although most reproductive organs from high dose and control animals underwent macroscopic and microscopic evaluation.

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