Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Justification for classification or non-classification

There is no information available for trilithium orthophosphate concerning skin sensitisation.

Concerning this endpoint, the lithium ion is considered to be the main toxophore, as phosphate ions are widely distributed throughout the organism (e.g. as structural material of bone and teeth and in form of adenosine phosphates ADP and ATP).

There is one study summary for Lithium chloride (CAS# 7447-41-8) publicly available on the homepage of the ECHA (European Chemicals Agency; disseminated dossier for Lithium chloride). This study is said to be performed according to OECD TG 406. Lithium chloride was found to be non-sensitizing.

Another study summary for Lithium carbonate (CAS# 554-13-2; disseminated dossier for Lithium chloride; ECHA homepage) is publicly available and the overall conclusion of this study (according to OECD TG 406) is, that the test material is non-sensitizing.

Based on a weight of evidence approach, trilithium orthophosphate is not classified for skin sensitisation in accordance to Directive 67/548/EEC and in accordance to EU CLP (Regulation (EC) No. 1272/2008) and UN GHS.