Registration Dossier

Administrative data

Endpoint:
fish, juvenile growth test
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The presented data have been retrieved from US EPA's ECOTOX Database, Version 4 (2012). This database provides single chemical toxicity information for aquatic and terrestrial life. The concomitant information within the database (such as indentification of guidelines and methods used) is reduced to the necessary minimum and usually not reported. Nevertheless, the toxicity data deposited has been derived from peer-reviewed literature and can therefore be regarded as valid information.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Lithium Chloride: A Flow-Through Embryo-Larval Toxicity Test with the Fathead Minnow, Pimephales promelas Rafinesque.
Author:
Long KE, Brown RP Jr., Woodburn KB
Year:
1998
Bibliographic source:
Bull. Environ. Contam. Toxicol. 60, 312-317
Reference Type:
secondary source
Title:
ECOTOX: Aquatic Report
Author:
U.S. EPA
Year:
2012
Bibliographic source:
ECOTOX Database Version 4.0

Materials and methods

Principles of method if other than guideline:
A test guideline is not available.
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Lithium chloride
EC Number:
231-212-3
EC Name:
Lithium chloride
Cas Number:
7447-41-8
IUPAC Name:
lithium chloride

Sampling and analysis

Analytical monitoring:
no

Test organisms

Test organisms (species):
Pimephales promelas
Details on test organisms:
- Test organism: Fathead minnow
- Age of fish: < 24 h

Study design

Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
26 d

Test conditions

Hardness:
56 - 70 mg/L CaCO3
pH:
7.2 - 7.5

Results and discussion

Effect concentrations
Duration:
26 d
Dose descriptor:
NOEC
Effect conc.:
0.2 mg/L
Nominal / measured:
nominal
Conc. based on:
element
Remarks:
Lithium
Basis for effect:
growth rate
Remarks:
(length)
Remarks on result:
other: equivalent to 1.12 mg/L Li3PO4
Details on results:
Conversion:
0.2 mg/L : 6.94 u (atomic weight of Li) = 0.029 mmol/L
0.029 mmol/L : 3 = 0.0097
0.0097 x 115.82 (molecular weight of Li3PO4) = 1.12 mg/L

Applicant's summary and conclusion