Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: early study report, but basic information given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1968
Report Date:
1968

Materials and methods

Principles of method if other than guideline:
modified Draize test
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
H3.NTA ("TRILON AS"), solid

Test animals

Species:
rabbit
Strain:
Vienna White

Test system

Type of coverage:
occlusive
Vehicle:
water
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
80%ige aqueous paste
Duration of treatment / exposure:
Exposure times: 1, 5, 15 min, and 20 h
Observation period:
24 h and 8 d p.a.
Number of animals:
2

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 8 d
Score:
0
Reversibility:
fully reversible
Irritant / corrosive response data:
no edema, very slight erythema after all intervals, completely reversible within 8 days

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU