Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: restriction: short study description; original data not available

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
1968

Materials and methods

Principles of method if other than guideline:
no information about test method
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
NTA monohydrate, 25% aqueous solution

Test animals

Species:
rabbit
Strain:
not specified
Sex:
male/female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
water
Duration of exposure:
up to 24 hours
Doses:
1000, 1580, 2510, 3980, 6310, 10000 mg/kg
No. of animals per sex per dose:
1
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 10 000 mg/kg bw
Clinical signs:
No nervousness or muscular incoordination developed. Activity and appetite reduced for 2-3 days at the higher levels; mild weakness.

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU