Registration Dossier
Registration Dossier
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EC number: 205-355-7 | CAS number: 139-13-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: early study report, but basic information given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
- Principles of method if other than guideline:
- internal BASF guidelines
- GLP compliance:
- no
Test material
- Reference substance name:
- Trilon AS
- IUPAC Name:
- Trilon AS
- Reference substance name:
- Nitrilotriacetic acid
- EC Number:
- 205-355-7
- EC Name:
- Nitrilotriacetic acid
- Cas Number:
- 139-13-9
- Molecular formula:
- C6H9NO6
- IUPAC Name:
- 2-[bis(carboxymethyl)amino]acetic acid
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: US rats
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 2, 16 and 30% aqueous suspension with traganth
- Details on oral exposure:
- Observation period: 14 days
- Doses:
- 200, 1600, 3200, 6400 mg/kg
- No. of animals per sex per dose:
- 20
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 6 400 mg/kg bw
- Mortality:
- see table below
- Clinical signs:
- other: 3200 - 6400 mg/kg: immediately accelerated breathing, high-stepping gait, disturbed behaviour. 3 days thereafter no symptoms, then deterioration of health with crusty eyes and noses, intermittent breathing and with intensively ruffled fur. The animals wer
- Gross pathology:
- Sacrificed animals: no abnormalities detected.
Any other information on results incl. tables
| Dose (mg/kg) | Concentration (%) | No. of animals | Dead animals after | ||||
| 1 hour | 24 hours | 48 hours | 7 days | 14 days | |||
| 6400 | 30 | 20 | 0/20 | 0/20 | 0/20 | 3/20 | 4/20 |
| 3200 | 30 | 20 | 0/20 | 0/20 | 0/20 | 1/20 | 1/20 |
| 1600 | 16 | 20 | 0/20 | 0/20 | 0/20 | 0/20 | |
| 200 | 2 | 20 | 0/20 | 0/20 | 0/20 | 0/20 | |
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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