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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Additional information

The test substance resulted in an acute oral LD50 value of > 6400 mg/kg for male and female rats (according to BASF-internal standards). Trilon AS was given in doses of 200, 600, 3200 and 6400 mg/kg as an aqueous suspension with traganth. Accelerated breathing and high stepping gait were the most prominent clinical signs. Mortalities were seen at 6400 mg/kg (3/20 after 7 days and 4/20 after 14 days) and at 3200 mg/kg (1/20 after 7 days and 14 days). Necropsy of the sacrificed animals showed no organ abnormalities (BASF, 1968).

An inhalation study with Trilon A (CAS No. 5064 -31 -3) resulted in a LC50 value of > 5 mg/l/4 hours for male rats (testing method according to Procter & Gamble). Concentrations given were 3.3, 3.5 and 5.0 mg/l. No mortalities were observed. Clinical signs were salivation, slow laboured respiration, partially open eyes and hypoactivity. These signs recovered after 1 - 2 days and the animals appeared to normal and healthy during the remainder of the 2-week observation period (EPA, 1980).

TNO (2007) found a RD50 value of 4.25 mg/l air for 30 minutes (test substance: Trilon A, CAS No. 5064 -31 -3). This test was done according to OECD guideline 403. Concentrations tested were 0.91 mg/l, 2.86 mg/l and 4.25 mg/l; male Wistar rats were used. The results of this study showed sensory irritation to be present in rats at levels of 2.86 and 4.25 mg/l.

An inhalation hazard test (BASF, 1968) showed no mortalities and no clinical signs in rats when given Trilon AS for 8 hours.

Monsanto (1968) found a dermal LD50 value of > 10000 mg/kg for male and female rabbits when given NTA monohydrate as 25% aqueous solution in doses of 1000, 1580, 2510, 3980, 6310 and 10000 mg/kg (occlusive conditions, exposure up to 24 hours).

Justification for classification or non-classification

Classification regarding acute oral toxicity is not warranted.

No studies for acute dermal and inhalation toxicity are available for this compound.