Registration Dossier
Registration Dossier
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EC number: 205-355-7 | CAS number: 139-13-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
The test substance resulted in an acute oral LD50 value of > 6400 mg/kg for male and female rats (according to BASF-internal standards). Trilon AS was given in doses of 200, 600, 3200 and 6400 mg/kg as an aqueous suspension with traganth. Accelerated breathing and high stepping gait were the most prominent clinical signs. Mortalities were seen at 6400 mg/kg (3/20 after 7 days and 4/20 after 14 days) and at 3200 mg/kg (1/20 after 7 days and 14 days). Necropsy of the sacrificed animals showed no organ abnormalities (BASF, 1968).
An inhalation study with Trilon A (CAS No. 5064 -31 -3) resulted in a LC50 value of > 5 mg/l/4 hours for male rats (testing method according to Procter & Gamble). Concentrations given were 3.3, 3.5 and 5.0 mg/l. No mortalities were observed. Clinical signs were salivation, slow laboured respiration, partially open eyes and hypoactivity. These signs recovered after 1 - 2 days and the animals appeared to normal and healthy during the remainder of the 2-week observation period (EPA, 1980).
TNO (2007) found a RD50 value of 4.25 mg/l air for 30 minutes (test substance: Trilon A, CAS No. 5064 -31 -3). This test was done according to OECD guideline 403. Concentrations tested were 0.91 mg/l, 2.86 mg/l and 4.25 mg/l; male Wistar rats were used. The results of this study showed sensory irritation to be present in rats at levels of 2.86 and 4.25 mg/l.
An inhalation hazard test (BASF, 1968) showed no mortalities and no clinical signs in rats when given Trilon AS for 8 hours.
Monsanto (1968) found a dermal LD50 value of > 10000 mg/kg for male and female rabbits when given NTA monohydrate as 25% aqueous solution in doses of 1000, 1580, 2510, 3980, 6310 and 10000 mg/kg (occlusive conditions, exposure up to 24 hours).
Justification for classification or non-classification
Classification regarding acute oral toxicity is not warranted.
No studies for acute dermal and inhalation toxicity are available for this compound.
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