Registration Dossier

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

No indication that induction or saturation of urinary excretion of Trilon A 92 occurs after repeated oral administration for 7 days (BASF, 1997). This test was done according to OECD guideline No. 417. The test substance (Trilon A 92) was either given as single oral dose of 500 or 25 mg/kg or daily for 7 days at a dose of 500 mg/kg to male Wistar rats.

In an OECD guideline study with 428 Trilon A, no appreciable diffusion of the test substance into or through the skin was found. Skin preparations of 4 donors were used within the study. The radiolabelled test substance was available as a solution in water (concentrations ragend from 100 - 4000 ug/cm2 resp. 10 - 400 mg/kg (BASF, 2008).