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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Description of key information

The estimated BCF of C12-C18 TMAC according to the BCFBAF v3.01 of EPIWEB v4.1, was 67.25 L/kg wet weight (log BCF = 1.78) which indicates a low potential to bioaccumulate. This is supported by an experimental BCF value of 79 determined for structurally similar C12-C16 ADBAC in bluegill fish.

Key value for chemical safety assessment

BCF (aquatic species):
67.25 L/kg ww

Additional information

The bioaccumulation potential of C12-C18 TMAC was estimated to be 67.25 L/kg wet weight (log BCF = 1.78) according to the BCFBAF v3.01 model of EPIWEB v4.1. Based on this data and considering the ready biodegradability, it can be assumed that the substance is expected to have a low bioaccumulation potential.

In a guideline study conducted with structurally similar substance C12-C16 ADBAC the bioaccumulation potential inLepomis macrochirus(bluegill fish) was determined. Bluegill fish (190 in number) were continuously exposed to the nominal concentration of 0.050 mg/L of the test substance (i.e., equivalent to a measured concentration of 0.076 mg/L) in well water for 35 days after which 35 fish were transferred to flowing, un-contaminated water for 21 days depuration period. Sampling intervals for the exposure period were Days 0, 1, 3, 7, 9, 10, 14, 21, 23, 28 and 35 and Days 1, 3, 7, 10, 14 and 21 for the depuration period. In addition water samples were also removed on Day 8 of the exposure period and Day 16 of the depuration.

Radiometric analyses of the water and selected fish tissues revealed the following:

- The mean steady state BCF factor in the edible, non-edible and whole body tissue during the 35 days of exposure were determined to be 33, 160 and 79.

- Half-life for non-edible tissue was attained between Days 14 and 21. By Day 21, the fish had eliminated 29%, 60% and 44% of the14C residues that had been present on the last day of exposure on each of the tissues (i. e., edible, non-edible and whole body tissues respectively)

- The concentration of the residual test substance on the skin was observed to be higher than those found in the total edible tissue (skin and muscle combined) indicating significant binding of the test substance to skin and scales of fish.


In conclusion the whole body BCF of the test substance was determined to be 79 indicating a low potential to bioaccumulate.