Registration Dossier
Registration Dossier
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EC number: 272-930-7 | CAS number: 68921-07-3 A complex combination of hydrocarbons obtained by treating a petroleum fraction with hydrogen in the presence of a catalyst.
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In the key study (Klimisch score = 2,API 1985b), 10 male Hartley albino guinea pigs were dermally exposed to light catalytically cracked distillate in an induction phase and then a subsequent challenge dose. Undiluted test material was applied under occlusion at a dose volume of 0.4 mL in all instances. One control animal was found dead on day 16. Following the challenge application, very slight erythema was present in three of the nine surviving animals. The other test animals exhibited no reaction following challenge treatment. The naïve control group also exhibited very slight erythema in three of the control animals, indicating a lack of a sensitising response in the treated animals.
In five supporting studies, cracked gas oils were not found to be sensitisers to guinea pigs.
Based on these results, cracked gas oils are not skin sensitisers when tested using a closed patch technique in guinea pigs.
Migrated from Short description of key information:
Cracked gas oils are not skin sensitisers when tested using a closed patch technique in guinea pigs.
Justification for selection of skin sensitisation endpoint:
One of six studies showing no effect
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Cracked gas oils are not classified as skin sensitisers according to EU CLP Regulation (EC No. 1272/2008) criteria.
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