Registration Dossier
Registration Dossier
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EC number: 200-893-9 | CAS number: 75-71-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Not specified
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
- Remarks:
- General overview of study results is presented, in accordance with EPA reporting rule on certain pesticide inert ingredients. No specific methodology is detailed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Guideline:
- other: No test guideline mentioned
- Principles of method if other than guideline:
- EPA reporting rule on certain pesticide inert ingredients (Section 8 (d) of the Toxic Substances Control Act (Fed. Vol. 54, No. 38, Tuesday, February 28, 1989)). No specific methodology is detailed in the available cover letter.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dichlorodifluoromethane
- EC Number:
- 200-893-9
- EC Name:
- Dichlorodifluoromethane
- Cas Number:
- 75-71-8
- Molecular formula:
- CCl2F2
- IUPAC Name:
- dichlorodifluoromethane
- Test material form:
- other: not specified.
- Details on test material:
- Not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- Not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- Not specified
- Doses:
- Not specified
- No. of animals per sex per dose:
- Not specified
- Control animals:
- not specified
- Details on study design:
- Not specified
- Statistics:
- Not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Based on:
- not specified
- Mortality:
- No deaths
- Clinical signs:
- Not specified
- Body weight:
- Not specified
- Gross pathology:
- Not specified
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 > 1000 mg/kg. It should be noted that this study could be waived as it is not relevant to the expected exposure to the substance. This is in accordance with Annex VII, Section 8.5.1 which states that
8.5.1. By oral route - The study need not be conducted if a study on acute toxicity by the inhalation route (8.5.2) is available.”
However, this study is included as supporting information to fulfil this data endpoint.
Although a limit test at > 1000 mg/kg no classification is proposed for oral toxicity, as this route of exposure is not anticipated. - Executive summary:
LD50 > 1000 mg/kg in a limit test. This study is included as supporting information to fulfil this data endpoint.
Although a limit test at > 1000 mg/kg no classification is proposed for oral toxicity, as this route of exposure is not anticipated.
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