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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: Predicted data
Title:
R: QSAR Toolbox 2.3.0.1132 prediction for "Effect LOEL" read across evaluation for 130-26-7
Author:
Sustainability Support Services (Europe) AB
Year:
2013
Bibliographic source:
QSAR Toolbox version 2.3

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Estimated data
Principles of method if other than guideline:
Prediction is done using QSAR Toolbox version 2.3.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Clioquinol
EC Number:
204-984-4
EC Name:
Clioquinol
Cas Number:
130-26-7
Molecular formula:
C9H5ClINO
IUPAC Name:
5-chloro-7-iodoquinolin-8-ol
Details on test material:
- Name of test material (as cited in study report): clioquinol
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
Fischer 344
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
28 days
Frequency of treatment:
weekly 5
Control animals:
not specified

Results and discussion

Results of examinations

Body weight and weight changes:
effects observed, treatment-related
Description (incidence and severity):
body weight decrease

Effect levels

Dose descriptor:
LOEL
Effect level:
159.486 other: mg/kg/day
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: not specified
Remarks on result:
other: not specified

Target system / organ toxicity

Critical effects observed:
not specified
Organ:
not specified

Any other information on results incl. tables

The prediction was based on dataset comprised from the following descriptors: "effect LOEL"
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(("a" or "b" or "c" or "d" or "e" or "f" ) and ("g" and "h" ) )

Domain logical expression index: "a"

Referential boundary: The target chemical should be classified as Phenols (Acute toxicity) by US-EPA New Chemical Categories

Domain logical expression index: "b"

Referential boundary: The target chemical should be classified as Arene AND Aryl halide AND Heterocyclic fragment AND Phenol AND Pyridine(substituted) by Organic functional groups

Domain logical expression index: "c"

Referential boundary: The target chemical should be classified as Aryl AND Aryl halide AND Fused heterocyclic aromatic AND Phenol AND Pyridine AND Quinoline/ Isoquinoline by Organic Functional groups (extended)

Domain logical expression index: "d"

Referential boundary: The target chemical should be classified as Aryl halide AND Heterocyclic fragment AND Phenol AND Pyridine(substituted) by Organic functional groups (nested)

Domain logical expression index: "e"

Referential boundary: The target chemical should be classified as Aryl halide AND Overlapping groups AND Phenol AND Quinoline/ Isoquinoline by Organic Functional groups (nested)(extended)

Domain logical expression index: "f"

Referential boundary: The target chemical should be classified as Aromatic compound AND Aryl chloride AND Aryl halide AND Aryl iodide AND Halogen derivative AND Hydroxy compound AND Phenol by Organic functional groups, Norbert Haider (checkmol)

Domain logical expression index: "g"

Parametric boundary:The target chemical should have a value of log Kow which is >= 2.61

Domain logical expression index: "h"

Parametric boundary:The target chemical should have a value of log Kow which is <= 3.64

Applicant's summary and conclusion

Conclusions:
The repeated dose toxicity LOEL (Lowest observed effect level) of clioquinol to rat by the inhalation route was estimated at a dose concentration of 159.4855 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to rat by the inhalative route below the above mentioned dose.
Executive summary:

The repeated dose toxicity LOEL (Lowest observed effect level) of clioquinol to rat by the inhalation route was estimated at a dose concentration of 159.4855 mg/kg bw/day.On the basis of this LOEL value it is concluded that the test substance is not toxic to rat by the inhalative route below the above mentioned dose.