Registration Dossier
Registration Dossier
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EC number: 204-984-4 | CAS number: 130-26-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Comparison of the Acute Toxicity of Clioquinol, Histamine, and Chloroform in Different Strains of Mice
- Author:
- C. Pericin, P. Thomann
- Year:
- 1 979
- Bibliographic source:
- Archives of Toxicology Volume 2, pp 371-373
- Reference Type:
- review article or handbook
- Title:
- DPIM : CHR500
- Author:
- Richard J. Lewis, Sr.
- Year:
- 2 007
- Bibliographic source:
- SAX (Sax's Handbook of Dangerous Industrial Materials):Archives of Toxicology, Supplement. 2 (1979), 371.
- Reference Type:
- review article or handbook
- Title:
- RTECS NUMBER : VC5075000
- Author:
- RTECS Database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances): ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- Volume(issue)/page/year: 2,371,1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Clioquinol
- EC Number:
- 204-984-4
- EC Name:
- Clioquinol
- Cas Number:
- 130-26-7
- Molecular formula:
- C9H5ClINO
- IUPAC Name:
- 5-chloro-7-iodoquinolin-8-ol
- Details on test material:
- - Name of test material (as cited in study report): clioquinol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 69 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Details of toxic effects not reported other than lethal dose value
- Mortality:
- Lethal dose, 50 percent kill
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of clioquinol in rodent - mouse was found to be 69 mg/kg of body weight. Acute toxicity of clioquinol to rodent - mouse by oral route indicates that clioquinol exhibits acute toxicity by the oral route in category 3.
- Executive summary:
The acute oral median lethal dose (LD50) of clioquinol in rodent - mouse was found to be 69 mg/kg of body weight. Acute toxicity of clioquinol to rodent - mouse by oral route indicates that clioquinol exhibits acute toxicity by the oral route in category 3.
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