Registration Dossier
Registration Dossier
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EC number: 206-735-5 | CAS number: 371-40-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Reaxys ID : 742030
- Year:
- 2 011
- Bibliographic source:
- Reaxys by Elsevier Properties SA; Okazaki, Yoshimasa; Yamashita, Kotaro; Ishii, Hiroyuki; Sudo, Masato; Tsuchitani, Minoru; Journal of Applied Toxicology; vol. 23; nb. 5; (2003); p. 315 - 322
- Reference Type:
- review article or handbook
- Title:
- RTECS Number: BY1575000
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances):- Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- Volume(issue)/page/year: 23,315,2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Standard acute method
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 4-fluoroaniline
- EC Number:
- 206-735-5
- EC Name:
- 4-fluoroaniline
- Cas Number:
- 371-40-4
- Molecular formula:
- C6H6FN
- IUPAC Name:
- 4-fluoroaniline
- Details on test material:
- - Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male
Administration / exposure
- Route of administration:
- other: peroral
- Vehicle:
- olive oil
- Doses:
- 100 - 1000 mg/kg
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- Rats were treated with title compound; body weights recorded on days 2, 4, 8, 15, 16 post-dose; mortality and clinical signs observed at 30 min and 5 h after dosing and once a day for following 15 days
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- other: TDLo
- Effect level:
- 600 mg/kg bw
- Based on:
- dissolved
- Remarks on result:
- other: Other details not available
- Clinical signs:
- other: Spinal Cord - other degenerative changes Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage); recording from peripheral motor nerve; structural change in nerve or sheath Behavioral - alteration of class
- Other findings:
- Rats treated with 4-fluoroaniline showed cyanosis between days 1 and 4 and irregular respiration on day 1; mean body weights of treated rats
decreased on day 2 and were significantly lower than those of control on days 4, 8, 15 and 16
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Oral toxicity (TDLo) of 4-fluoroaniline to rat was examined at dose concentration of 600 mg/kg of body weight.
- Executive summary:
The potential for neurotoxicity after a single oral dose of 4-fluoroaniline (4-FA), given to rats, was investigated at or near the lethal dosage level. Hindlimb paralysis was found clinical observation, with the maximum incidence of 100% in 4-FA groups.
Oral toxicity (TDLo) of 4-fluoroaniline to rat was examined at dose concentration of 600 mg/kg of body weight.
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