Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 371-40-4
Author:
Danish EPA Model
Year:
2012
Bibliographic source:
QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:DK-EPA

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Modelling database
Principles of method if other than guideline:
Multicase model is used to estimate LC50 (48h) of Daphnia.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
other: Estimation
Water media type:
not specified
Total exposure duration:
48 h

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
3.2 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality

Applicant's summary and conclusion

Conclusions:
The LC50 value of 4-fluoroaniline to Daphnia magna during a 48hr exposure is 3.2 mg/L
Executive summary:

The EC50 value of 4-fluoroaniline to Green algae during a 48 hr exposure is estimated to be 3.2 mg/L.Though short term toxicity values to aquatic species indicate that the chemical could be classified for aquatic toxicity, but since 4-fluoroaniline is readily biodegradable in water and also is very water soluble and given the large dilution possibility in the aquatic environment, it is concluded that 4-fluoroaniline shall not exhibit toxicity to the aquatic organisms and the aquatic environment.