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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Referenceopen allclose all

Reference Type:
other: QSAR toolbox
Title:
QSAR study for CAS: 371-40-4
Year:
2011
Bibliographic source:
OECD QSAR toolbox version 2.2, 2011:- Steven J. Broderius, Michael D. Kahl, Marilynn D. Hoglund; Use of joint toxic response to define the primary mode of toxic action for diverse industrial organic chemicals; Environ. Toxicol. Chem.14(9): 1591-1605,1995.
Reference Type:
review article or handbook
Title:
Reference ID: 15031
Year:
2012
Bibliographic source:
ECOTOX (ECOTOXicology database):- Steven J. Broderius, Michael D. Kahl, Marilynn D. Hoglund; Use of joint toxic response to define the primary mode of toxic action for diverse industrial organic chemicals; Environ. Toxicol. Chem.14(9): 1591-1605,1995.
Reference Type:
review article or handbook
Title:
Reaxys ID: 742030
Year:
2011
Bibliographic source:
Reaxys by Elsevier Properties SA; Broderius, Steven J.; Kahl, Michael D.; Hoglund, Marilynn D.; Environmental Toxicology and Chemistry; vol. 14; nb. 9; (1995); p. 1591 - 1606

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from OECD QSAR Toolbox and US EPA ECOTOX Database
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
not specified

Test organisms

Test organisms (species):
Pimephales promelas
Details on test organisms:
Age: 26-34 day(s)
Lifestage: JUVENILE

Study design

Test type:
flow-through
Water media type:
freshwater
Total exposure duration:
4 d

Test conditions

Hardness:
45 milligrams per liter Calcium ca
Test temperature:
25 Celsius
pH:
7.8
Details on test conditions:
Water alkalinity: 42 milligrams per liter Calcium ca

Results and discussion

Effect concentrations
Duration:
4 d
Dose descriptor:
LC50
Effect conc.:
23 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality

Applicant's summary and conclusion

Conclusions:
The LC50 value of 4-fluoroaniline to Fathead minnow during a 96hr flowthrough exposure is 16.9 mg/L and 23 mg/L
Executive summary:

The LC50 value of 4-fluoroaniline to Fathead minnow during a 96hr flowthrough exposure is 16.9 mg/L and 23 mg/L. Though short term toxicity values to aquatic species indicate that the chemical could be classified for aquatic toxicity, but since 4-fluoroaniline is readily biodegradable in water and also is very water soluble and given the large dilution possibility in the aquatic environment, it is concluded that 4-fluoroaniline shall not exhibit toxicity to the aquatic organisms and the aquatic environment.