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EC number: 928-253-0
CAS number: 1174918-40-1
Table 7.2.3/2: Individual animal weights
Table 7.2.3/3: Necropsy observation
STOMACH : contains slight amount of hair with ingesta
KIDNEYS (both) : medulla slightly reddened
STOMACH : slight amount of hair present with ingesta
No observable abnormalities
Table 7.2.3/4: Irritant/corrosive response
data for each animal at each observation time:
Score at time point
Max. score: 4
-207 was tested for acute dermal toxicity in New Zealand rabbits in a
limit dose assay similar to OECD guideline N°402. The test substance, a
liquid, was administered undiluted. Hair was removed from to the backs
of animals with clippers. The assay was conducted on a group of 6
rabbits (3 males, 3 females) with a dose of 3160 mg/kg b.w. administered
in a single dermal dose. The test substance was applied for 24 hours
under an occlusive patch. Skin was wiped at the end of the 24-hour
exposure period to remove remaining test substance.
for mortality, clinical signs and body weight gain were performed during
the 14 -day observation period. All surviving animals were necropsied at
the end of the observation period.
No deaths and clinical signs occurred during the observation period.
weight gain was not affected by treatment. At necropsy, macroscopic
examination of main organs showed no abnormalities.
signs were recorded up to Day 14. Moderate to severe erythema was
observed in all rabbits at the end of exposure while very slight edema
was only observed in one animal. Then, no edema was observed in any
rabbits. Very slight erythema was still observed in 4 animals by day 10.
At the end of observation period (day 14), very slight erythema was
still recorded in two females.
the acute dermal LD50 was greater than 3160 mg/kg b.w. under the
conditions of the test, MRD-83-207 is not classified according to the
criteria of Annex VI to Directive 67/548/EEC and CLP Regulation
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