3-dimethylaminopropan-1-ol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented study report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Principles of method if other than guideline:

Method: BASF-Test: Animals were treated for 1, 5, 15 min and 20 hours using occlusive conditions. An application site of 2.5x2.5 cm was covered with the liquid test substance. After the application time (1, 5 and 15 min) the skin was washed with Lutrol (50%). The animals were observed for 8 days and skin changes were recorded daily. The report describes findings after 24 hours and at the end of the observation period (8 days). For a final evaluation, the findings after 48 h and 72 h from the raw data were taken into account.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-dimethylaminopropan-1-ol

EC Number:

221-659-2

EC Name:

3-dimethylaminopropan-1-ol

Cas Number:

3179-63-3

Molecular formula:

C5H13NO

IUPAC Name:

3-(dimethylamino)propan-1-ol

Details on test material:

Name of the test substance used in the study report: N,N-Dimethyl-propanolamin

Test animals

Species:

rabbit

Strain:

Vienna White

Test system

Type of coverage:

occlusive

Preparation of test site:

other: intact skin

Vehicle:

unchanged (no vehicle)

Controls:

other: untreated skin of the same animal

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied (volume or weight with unit): about 1 ml

Duration of treatment / exposure:

1, 5 , 15 min and 20 h

Observation period:

8 d

Number of animals:

2

Details on study design:

TEST SITE
- Area of exposure: 2.5 x 2.5 cm (patch test)

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Remarks:

1 min exposure

Basis:

mean

Time point:

other: 24 h - 8 d

Score:

0

Max. score:

4

Results 2

Irritation parameter:

erythema score

Remarks:

5 min exposure

Basis:

mean

Time point:

other: 24 h - 8 d

Score:

0

Max. score:

4

Results 3

Irritation parameter:

erythema score

Remarks:

15 min exposure

Basis:

mean

Time point:

other: 24 h - 8 d

Score:

1 - 2

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: necrosis, staining, scaling

Results 4

Irritation parameter:

erythema score

Remarks:

20 h exposure

Basis:

mean

Time point:

other: 24 h - 8 d

Score:

2 - 3

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: necrosis, anaemia, leatherlike skin

Results 5

Irritation parameter:

edema score

Remarks:

1 min exposure

Basis:

mean

Time point:

other: 24 h - 8 d

Score:

0

Max. score:

4

Results 6

Irritation parameter:

edema score

Remarks:

5 min exposure

Basis:

mean

Time point:

other: 24 h - 8 d

Score:

0

Max. score:

4

Results 7

Irritation parameter:

edema score

Remarks:

15 min exposure

Basis:

mean

Time point:

other: 24 h - 8 d

Score:

1 - 2

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: necrosis, staining, scaling

Results 8

Irritation parameter:

edema score

Remarks:

20 h exposure

Basis:

mean

Time point:

other: 24 h - 8 d

Score:

2 - 3

Max. score:

4

Reversibility:

not fully reversible within: 8 days

Remarks on result:

other: necrosis, anaemia, leatherlike skin

Irritant / corrosive response data:

After 8 days, strong/movable necrosis was observed (both animals).

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information