Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Variety of data sources and peer reviewed data.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
SIDS INITIAL ASSESSMENT PROFILE
Author:
OECD
Year:
2011
Bibliographic source:
UNEP publications
Report date:
2011
Reference Type:
secondary source
Title:
Unnamed
Year:
2012
Report date:
2012
Reference Type:
secondary source
Title:
Log octanol/water coefficient, log Pow
Author:
HANSCH,C ET AL.
Year:
1995
Bibliographic source:
ChemIDplus (SRC PhysProp Database): HANSCH,C ET AL. (1995)
Reference Type:
secondary source
Title:
Log octanol/water coefficient, log Pow
Author:
MITI
Year:
1992
Bibliographic source:
eChemPortal: MITI 1992. Biodegradation and bioaccumulation data of existing chemicals based on the CSCL Japan. Compild under the Safety Division Basic Industries Bureau Ministry of International Trade & Industry, Japan.

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No further details
GLP compliance:
not specified
Partition coefficient type:
octanol-water

Test material

Constituent 1
Chemical structure
Reference substance name:
Thiophene
EC Number:
203-729-4
EC Name:
Thiophene
Cas Number:
110-02-1
Molecular formula:
C4H4S
IUPAC Name:
thiophene

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
1.81
Remarks on result:
other: Reference: SIDS Initial assessment report 2011 and HANSCH, C et AL. 1995
Type:
log Pow
Partition coefficient:
1.81
pH:
10
Remarks on result:
other: Reference: MSDS Sanofi 2012
Type:
log Pow
Partition coefficient:
1.86
Remarks on result:
other: Reference: MITI 1992

Applicant's summary and conclusion

Conclusions:
The reported Partition coefficient Log Pow values in several sources are between 1.81 and 1.86