Registration Dossier
Registration Dossier
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EC number: 214-688-7 | CAS number: 1185-81-5
Water solubility
Administrative data
Link to relevant study record(s)
Description of key information
The water solubility of the test item has been determined to be in the range 3.22 x 10-4 to 5.74 x 10-4 g/l of solution at 20.0 ± 0.5°C when applying the standard saturation and equilibration times specified within the test method guidelines, with a decreasing concentration observed on extension of the initial saturation period. Testing used a flask method, designed to be compatible with Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008 and Method 105 of the OECD Guidelines for Testing of Chemicals, 27 July 1995.
On applying a significantly reduced initial saturation period and final equilibration period of 1 hour at each stage, the resulting solubility was elevated to 6.26 x 10-4 g/l of solution at 20.0 ± 0.5°C. The maximum observed solubility of 9.90 x 10-4 g/l of solution at 20.0 ± 0.5°C was observed for the preliminary test where the initial saturation period and final equilibration period were 18½ hours and 3½ hours respectively.
However, analytical data may systematically overestimate the solubility of the parent test item, as although a chromatographic peak was resolved by the analytical method, even on the application of a mass selective detector, the analytical method may not have been substance specific to the test item. Organotin compounds, due to thermal instability, do not result in a detectable parent mass ion on analysis. The ion monitored analytically was that of a tin adduct with tropolone (introduced as a mobile phase additive), and therefore although analytical data did confirm the presence of a soluble, tin containing compound, it may have been influenced by the presence of more soluble tin containing impurities and/or hydrolysis products.
Key value for chemical safety assessment
Additional information
Vaue for CSA: In the range 3.22 x 10-4 to 5.74 x 10-4 g/l of solution at 20.0 ± 0.5°C
A reliability rating of 1 was assigned to the key study according to the criteria of Klimisch, 1997 as the study was conducted in accordance with recognised guidelines and GLP.
According to the EU Directive 67/548/EEC, a poorly soluble substance can be defined as a substance with a solubility of less than 1 mg/L.
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