Registration Dossier
Registration Dossier
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EC number: 218-378-2 | CAS number: 2137-18-0
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The hydrolytic stability of gestonorone was estimated on basis of its chemical structure and of the hydrolytic behaviour of a structurally similar compound.
General Physical Chemistry, Schering AG, Berlin. Study report A02229 (APC 196/00), dated 2000-11-07.
Result: Gestonorone can be expected to be hydrolytically stable in the pH region 4 to 9 (at 25°C).
Key value for chemical safety assessment
Additional information
The test substance does not contain any functional group, which is susceptible to hydrolytic degradation. Thus hydrolytic stability is to be expected.
This is experimentally supported by the results of a hydrolysis study with 17-Hydroxy-1 alpha,2 alpha-methylene-4,6-pregnadiene -3,20-dione, which differs in an additional double bond in ring B and a methyl group and a condensed 3 -ring at ring A. This compound and was found to be hydrolytically stable in the pH region 4 to 9.
The same behaviour is to be expected for gestonorone.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
