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Administrative data

Description of key information

LD50 oral (rat): > 5000 mg/kg bw [McLain et al. 1990]

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: short abstract
Principles of method if other than guideline:
no data
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes
Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
no data
Route of administration:
oral: gavage
Vehicle:
corn oil
Details on oral exposure:
- Application volume: 10 ml/kg
Doses:
5000 mg/kg
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
no data
Preliminary study:
no data
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.

No remarkable clinical signs.

Executive summary:

A single oral administration of the test substance by gavage to male and female rats at the limit-dose 5000 mg/kg was tolerated without remarkable clinical signs (LD50 > 5000 mg/kg body weight).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The acute oral toxicity of the test substance was low with a LD50 value exceeding 5000 mg/kg bw in male and female rats (McLain et al., 1990). At the limit-dose 5000 mg/kg no remarkable clinical signs were observed during the 14-day post observation period.


Justification for selection of acute toxicity – oral endpoint
Only one study available

Justification for classification or non-classification

Based on the study results a classification according to Directive 67/548/EEC or Regulation (EC) No. 1272/2008 (CLP) is not warranted.