Registration Dossier
Registration Dossier
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EC number: 942-322-2 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
3h EC50 (activated sludge, domestic) = 135 mg/L (respiration inhibition test, similar to OECD 209)
Key value for chemical safety assessment
- EC50 for microorganisms:
- 135 mg/L
Additional information
A weight of evidence approach was chosen in order to evaluate the toxicity of C12-14AS MEA (CAS 90583-16-7) to microorganisms.
Two studies presenting basic data for C12-14AS MEA (CAS 90583-16-7) are available. A GLP test according to DIN 38412 part 8 with Pseudomonas putida using was conducted by Guhl (1991a). In this study, the growth inhibition of Pseudomonas putida was recorded after approximately 16 hours of exposure. The 16-h EC10 value was determined to be 1769 mg a.i./L (nominal concentration). The second with C12-14AS MEA (CAS 90583-16-7) was performed also according to GLP and following DIN 38412, part 27. A 30 min EC0 value of >= 3050 mg a.i./L was reported based on the respiration rate of Pseudomonas putida.
Furthermore, the read-across substance C12AS Na (CAS 151-21-3) using activated sludge from a municipal sewage treatment plant rather than only a single species as inoculum (Dutka, 1983) was chosen for th weight of evidence approach. The read-across to the structurally related category member was conducted in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5. The non-GLP test with C12AS Na was performed according to a guideline similar to OECD 209. The EC50 values of 188 and 135 mg/L (nominal concentrations) were obtained for the endpoint respiration inhibition after 30 minutes and 3 hours of exposure, respectively. The 3-hour EC50 value of 135 mg/L, being the most sensitive value, was used for the PNEC STP derivation of C12-14AS MEA (CAS 90583-16-7).
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