Registration Dossier
Registration Dossier
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EC number: 237-881-8 | CAS number: 14044-65-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in mammalian cells
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only a one page summary of the results is available, no details on experimental set-up given; no information about positive and negative controls
Data source
Reference
- Reference Type:
- secondary source
- Title:
- BORANE-TETRAHYDROFURAN COMPLEX
- Bibliographic source:
- National Institutes of Health, CCRIS data base
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- not specified
- Type of assay:
- mammalian cell gene mutation assay
Test material
- Reference substance name:
- Tetrahydrofuran-borane
- EC Number:
- 237-881-8
- EC Name:
- Tetrahydrofuran-borane
- Cas Number:
- 14044-65-6
- Molecular formula:
- C4H11BO
- IUPAC Name:
- Borane-tetrahydrofuran (1:1)
Constituent 1
Method
- Test concentrations with justification for top dose:
- 7.3-15 mL/mL
- Vehicle / solvent:
- Vehicle: ethanol
- Details on test system and experimental conditions:
- L5178Y (TK+/TK-) were used and incubated with the test substance with and withou metabolic activation (S9)
Results and discussion
Test results
- Species / strain:
- mouse lymphoma L5178Y cells
- Metabolic activation:
- with and without
- Genotoxicity:
- positive
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
