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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1964
Report date:
1964

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
A test group consisting of 5 animals/sex was treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(dimethylamino)propan-2-ol
EC Number:
203-556-4
EC Name:
1-(dimethylamino)propan-2-ol
Cas Number:
108-16-7
Molecular formula:
C5H13NO
IUPAC Name:
1-(dimethylamino)propan-2-ol
Test material form:
liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): Dimethyl-isopropanolamin
- Physical state: liquid
no further data

Test animals

Species:
rat
Strain:
other: US-rats
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: males: 148-314 g, females: 110-170 g

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 2% or 20 % v/v

MAXIMUM DOSE VOLUME APPLIED:
16 ml/kg bw
Doses:
170, 680, 1360, 1700, 2125, 2720 mg/kg bw
No. of animals per sex per dose:
5-10
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs
Statistics:
no data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 1 360 mg/kg bw
Based on:
test mat.
Remarks on result:
other: ca. 1.6 ml/kg 20% (v/v)
Mortality:
0/10 animals died at 170 mg/kg bw
0/10 animals died at 680 mg/kg bw
10/20 animals died at 1360 mg/kg bw
10/20 animals died at 1700 mg/kg bw
6/10 animals died at 2125 mg/kg bw
9/10 animals died at 2720 mg/kg bw
deaths occured within day 1-3
Clinical signs:
On the day of administration: apathy, staggering, dyspnoea.
On the following days: calm behaviour, fluffy fur, crusted eyes.
The surviving aninmals were without findings within 4-6 days.
Body weight:
no data
Gross pathology:
haemorrhagic gastroenteritis in the dead animals, organs of the surviving animals without findings

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
oral LD50(rat) = ca. 1360 mg/kg bw