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Endpoint summary

Description of key information

No experimental toxicokinetic study is available on 2 moles Ethoxylated bisphenol A dimethacrylate. However, as per REACH guidance document R7.C, information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties.
Based on the toxicological data and the physicochemical properties, a low absorption of the substance is expected after oral, dermal or inhalation exposure.

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Absorption rate - oral (%):

50

Absorption rate - dermal (%):

50

Absorption rate - inhalation (%):

100

Additional information

No experimental toxicokinetic study is available on 2 moles Ethoxylated bisphenol A dimethacrylate. However, as per REACH guidance document R7.C, information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties, including:

-Molecular weight: 452 -540 g/mol

-Water solubility: 36.4 µg/L

-Partition coefficient Log Kow: 4.3 -6.2

-Vapour pressure: 0.117 10^-6 Pa (20°C)

 

ABSORPTION

The value of log Kow (>4) and the low water solubility are in the range suggestive of low absorption from the gastro-intestinal tract subsequent to oral ingestion. Indeed the absorption of highly lipophilic substances may be limited by the inability of such substances to dissolve into GI fluids.

This assumption of a low oral absorption is confirmed in the oral study: no systemic effect or mortality was observed in rats treated at 35 000 mg/kg bw in the acute toxicity study, and at 1000 mg/kg bw/d in the 28 and 90-day repeated toxicity studies.

With low water solubility, a high value of log Kow and a molecular mass near to 500 g/mol, dermal absorption is anticipated to be low. Moreover, the acrylates are known to bind to skin components, and this binding decreases their dermal absorption. In the dermal acute toxicity study, no systemic effect or mortality was observed in rats treated at 2000 mg/kg bw. Moreover, 2 moles Ethoxylated bisphenol A dimethacrylate showed no allergic reaction in the in vivo skin sensitization test.

Based on the very low value of the vapour pressure, 2 moles Ethoxylated bisphenol A dimethacrylate is not a volatile substance. With the low water solubility, no or very low absorption by inhalation is expected for this substance.

 

DISTRIBUTION and METABOLISM

The molecule is lipophilic (log Kow >4), it is likely to distribute into cells and the intracellular concentration may be higher than extracellular concentration particularly in fatty tissues. Some non adverse systemic effects were observed in the oral 90 -day repeated toxicity study in rats. 

No specific data is available on the metabolism of 2 moles Ethoxylated bisphenol A dimethacrylate.

 

ELIMINATION

Due to the low water solubility and a moderate molecular mass (near to 500 g/mol), the excretion of 2 moles Ethoxylated bisphenol A dimethacrylate in the urines is not expected. An excretion via bile and faeces is possible.