Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Results of an study conducted in accordance with generally accepted scientific principles. Possible deficiencies in the reporting of the endpoint do not affect the quality of relevant results.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1993

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes
Test type:
acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-diethylbenzene
EC Number:
203-265-2
EC Name:
1,4-diethylbenzene
Cas Number:
105-05-5
Molecular formula:
C10H14
IUPAC Name:
1,4-diethylbenzene
Details on test material:
1,4-diethylbenzene, purity 97.2%

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
not specified
Doses:
0 or 2000mg/kg

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
not specified
Mortality:
No death was observed in both during the course of the study.
Clinical signs:
As clinical signs, decrease of spontaneous motor activity was observed in both male and female rats and lacrimation was additionnally observed in one female rat.
Body weight:
All animals gained body weight on day 7 and 14 after administration.
Gross pathology:
No remarkable macroscopical changes were observed in both males and females.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

One oral acute toxicity data is available for rat, limit test done according to OECD Guideline 401. Rats were adminitered orally (gavage) 0 and 2000 mg/kg. Clinical signs observed were decrease of spontaneous motor activity (male/female) and lacrimation in one female rat. No deaths occured and no remarkable macroscopic changes were observed in both male/female. With this study a LD50 > 2000 mg/kg was determined.