Registration Dossier
Registration Dossier
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EC number: 203-810-4 | CAS number: 110-87-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Method: BASF-Test
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,4-dihydro-2H-pyran
- EC Number:
- 203-810-4
- EC Name:
- 3,4-dihydro-2H-pyran
- Cas Number:
- 110-87-2
- Molecular formula:
- C5H8O
- IUPAC Name:
- 3,4-dihydro-2H-pyran
- Details on test material:
- IUCLID4 Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- other: The adjacent eye served as saline control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 mm³ - Observation period (in vivo):
- up to 8 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Time point:
- other: 24 hrs
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Irritation parameter:
- chemosis score
- Time point:
- other: 24 hrs
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Time point:
- other: 24 hrs
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- On the basis of the findings, the test substance must be described as moderately irritating to the eyes.
- Executive summary:
On the basis of the findings, the test substance must be described as moderately irritating to the eyes. When the test substance acts on the eyes, corneal opacity must be expected. The pathological findings on the eye and the signs of irritation to the eye substantially subsided within 8 days.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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