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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: This study is classified as reliable with restriction because although it is pre-guideline, the study meets generally accepted scientific standards.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
exposure was for 24 hours as opposed to the guideline recommended 4 hours
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
1,1-dimethylheptanethiol (CAS # 25360-10-5)
IUPAC Name:
1,1-dimethylheptanethiol (CAS # 25360-10-5)
Details on test material:
t-nonyl mercaptan

Test animals

Species:
rat
Strain:
other: WBS/W
Sex:
male

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
TEST SITE
- Area of exposure: hair-clipped skin of the trunk
- Type of wrap if used: pre-fitted occluding sleeve

REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 hours
Duration of exposure:
24 hours
Doses:
Single dose of 2000 mg/kg
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: = (2.36 mL/kg)
Mortality:
All test animals survived.
Clinical signs:
other: All of the animals remained asymptomatic.
Gross pathology:
Not performed

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute dermal LD50 of 1,1-dimethylheptanethiol was determined to be >2000 mg/kg bw.
Executive summary:

In an acute dermal toxicity study, 6 male WBS/W rats were dermally administered a single dose of 1,1-dimethylheptanethiol at 2000 mg/kg bw. A pre-fitted occlusive sleeve was then placed on each animal and remained in place for 24 hours. The animals were subsequently observed for a period of 7 days.

 

None of the animals exhibited any clinical symptoms and no mortality was observed through the study period. Some loss in body weight was observed but was observed to have recovered one day later. Based on the lack of adverse toxicity observed, the acute dermal LD50 for 1,1 -dimethylheptanethiol was determined to be >2000 mg/kg bw.

 

This study received a Klimisch score of 2 and is classified as reliable with restriction because although it is pre-guideline, the study meets generally accepted scientific standards.